Novel topical formulation with antimicrobial peptides and plant extracts vs conventional for canine otitis externa
Novel topical formulation with antimicrobial peptides and plant extracts vs conventional for canine otitis externa
- 저자: Bannach Tatiana Charello; Mongruel Anna Claudia Baumel; Evangelista Alberto Gonçalves; de Souza Vitória Brigida Mielnik; Voi Renata; Otuki Michel Fleith; de Farias Marconi Rodrigues; Luciano Fernando Bittencourt
- 출처: Pathogens (Basel, Switzerland), 2025
- DOI/링크: 10.3390/pathogens14111112
- 분야 태그: #반려동물 #동물건강
- 정리일: 2026-07-11
TL;DR
These findings suggest that the plant-based formulation is a safe and effective alternative for managing canine OE, offering a promising solution to reduce the reliance on antibiotics and corticosteroids
1. 연구 배경 및 동기
- 다루는 문제: Canine otitis externa (OE) presents a significant challenge in veterinary medicine due to its complex, multifactorial nature and the growing issue of antimicrobial resistance (AMR) associated with conventional antibiotic use
- 기존의 공백 / 왜 필요한가: The objective of this study was to compare the efficacy of a novel, antibiotic-free topical ear solution (Therapy A) containing antimicrobial peptides and encapsulated plant extracts (chamomile, calendula, rosemary, and hops) against a standard conventional treatment (Therapy B) composed of gentamicin, betamethasone valerate, and clotrimazole. A longitudinal, randomized study was conducted over four weeks with 40 domestic dogs diagnosed with OE
2. 관련 연구
- 기존 연구 흐름: The dogs were divided into two groups, each receiving one of the therapies
- 이 논문의 위치: Animal Health 분야 내 기존 문헌 검토
| 구분 | 기존 연구 | 이 논문 |
|---|---|---|
| 주제 | 일반적 접근 | Novel 중심 |
3. 핵심 기여
- Notably, Therapy A was clinically effective in two of the three dogs presenting multi-drug resistant (MDR) bacterial infections
- The novel formulation also demonstrated a favorable safety profile, with no adverse drug reactions reported, in contrast to one dog in the conventional treatment group that experienced an adverse reaction
- These findings suggest that the plant-based formulation is a safe and effective alternative for managing canine OE, offering a promising solution to reduce the reliance on antibiotics and corticosteroids.
4. 제안 방법론
- 전체 접근 논리: Evaluations were performed weekly, assessing clinical signs using the Otitis Index Scoring System (OTIS-3) and a pruritus visual analog scale (pVAS), as well as ear canal pH and cytology
- 단계: The results showed that Therapy A provided similar clinical efficacy in OTIS-3 and pVAS scores that were comparable to Therapy B. Cytological analysis also revealed a significant reduction in microbial presence for both groups
5. 실험 설정
| 항목 | 내용 |
|---|---|
| 대상/재료 | Cytological analysis also revealed a significant reduction in microbial presence for both groups |
| 처리 조건 | The results showed that Therapy A provided similar clinical efficacy in OTIS-3 and pVAS scores that were comparable to Therapy B |
| 대조군 | - |
| 측정 방법 | Cytological analysis also revealed a significant reduction in microbial presence for both groups |
6. 실험 결과 분석
| 지표 | 변화(Δ) | 조건 · 유의성 |
|---|---|---|
| - | - | Notably, Therapy A was clinically effective in two of the three dogs presenting multi-drug resistant (MDR) bacterial infections |
제안 기전(인과 사슬): Notably, Therapy A was clinically effective in two of the three dogs presenting multi-drug resistant (MDR) bacterial infections. The novel formulation also demonstrated a favorable safety profile, with no adverse drug reactions reported, in contrast to one dog in the conventional treatment group that experienced an adverse reaction
7. 비판적 평가
강점
- These findings suggest that the plant-based formulation is a safe and effective alternative for managing canine OE, offering a promising solution to reduce the reliance on antibiotics and corticosteroids.
한계 · 의문
- 표본 크기 및 장기 추적 데이터 부재 가능성
8. 향후 연구 방향
- These findings suggest that the plant-based formulation is a safe and effective alternative for managing canine OE, offering a promising solution to reduce the reliance on antibiotics and corticosteroids.
9. 결론
Canine otitis externa (OE) presents a significant challenge in veterinary medicine due to its complex, multifactorial nature and the growing issue of antimicrobial resistance (AMR) associated with conventional antibiotic use 연구에서 evaluations were performed weekly, assessing clinical signs using the otitis index scoring system (otis-3) and a pruritus visual analog scale (pvas), as well as ear canal ph and cytology을 통해 notably, therapy a was clinically effective in two of the three dogs presenting multi-drug resistant (mdr) bacterial infections. These findings suggest that the plant-based formulation is a safe and effective alternative for managing canine OE, offering a promising solution to reduce the reliance on antibiotics and corticosteroids
Keywords
Novel, topical, formulation, antimicrobial, peptides, plant