Probiotic potential of LAB isolated from canine and feline microbiota

저자: Kiran Fadime; Demirhan Hazal Kibar; Sevin Sedat
출처: Veterinary research communications, 2026
DOI/링크: 10.1007/s11259-026-11242-z
분야 태그: #반려동물 #동물사료
정리일: 2026-07-11

TL;DR

faecium CM/BS2, emphasizing their suitability for inclusion in species-specific probiotic formulations aimed at supporting gastrointestinal and immune health in dogs and cats

1. 연구 배경 및 동기

다루는 문제: The global rise in pet ownership has increased demand for health-promoting products, particularly probiotics designed to support gastrointestinal and immune health in companion animals
기존의 공백 / 왜 필요한가: However, most commercial products rely on non-host-adapted strains, which may limit gastrointestinal colonization and host-specific benefits. To address this gap, 56 bacterial isolates were obtained from the fecal and milk microbiota of clinically healthy dogs and cats

2. 관련 연구

기존 연구 흐름: Both strains exhibited a safe profile, as evidenced by γ-hemolysis and susceptibility to a panel of clinically relevant antibiotics
이 논문의 위치: Animal Feed 분야 내 기존 문헌 검토

구분	기존 연구	이 논문
주제	일반적 접근	Probiotic 중심

3. 핵심 기여

Collectively, these findings highlight the probiotic potential of host-adapted L
reuteri DF/KS2 and E
faecium CM/BS2, emphasizing their suitability for inclusion in species-specific probiotic formulations aimed at supporting gastrointestinal and immune health in dogs and cats.

4. 제안 방법론

전체 접근 논리: Under simulated gastrointestinal conditions, CM/BS2 and DF/KS2 tolerated highly acidic environments and demonstrated resilience against digestive enzymes and bile salts
단계: Furthermore, both isolates displayed strong auto-aggregation and co-aggregation abilities with key pathogens, while adhesion assays using Caco-2 cells confirmed their capacity to inhibit pathogen attachment. Immunomodulatory evaluations further revealed that both strains effectively reduced pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and enhanced anti-inflammatory IL-10 production in canine and feline macrophages

5. 실험 설정

항목	내용
대상/재료	Immunomodulatory evaluations further revealed that both strains effectively reduced pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and enhanced anti-inflammatory IL-10 production in
처리 조건	Furthermore, both isolates displayed strong auto-aggregation and co-aggregation abilities with key pathogens, while adhesion assays using Caco-2 cells confirmed their capacity to inhibit pathogen attachment
대조군	-
측정 방법	Optimal growth occurred at 37 °C after 24 h in 2% molasses medium, and shelf-life studies demonstrated that freeze-dried cultures retained high viability over six months at - 20 °C

6. 실험 결과 분석

지표	변화(Δ)	조건 · 유의성
-	-	Collectively, these findings highlight the probiotic potential of host-adapted L

제안 기전(인과 사슬): Collectively, these findings highlight the probiotic potential of host-adapted L. reuteri DF/KS2 and E

7. 비판적 평가

강점

faecium CM/BS2, emphasizing their suitability for inclusion in species-specific probiotic formulations aimed at supporting gastrointestinal and immune health in dogs and cats.

한계 · 의문

표본 크기 및 장기 추적 데이터 부재 가능성

8. 향후 연구 방향

faecium CM/BS2, emphasizing their suitability for inclusion in species-specific probiotic formulations aimed at supporting gastrointestinal and immune health in dogs and cats.

9. 결론

The global rise in pet ownership has increased demand for health-promoting products, particularly probiotics designed to support gastrointestinal and immune health in companion animals 연구에서 under simulated gastrointestinal conditions, cm/bs2 and df/ks2 tolerated highly acidic environments and demonstrated resilience against digestive enzymes and bile salts을 통해 collectively, these findings highlight the probiotic potential of host-adapted l. faecium CM/BS2, emphasizing their suitability for inclusion in species-specific probiotic formulations aimed at supporting gastrointestinal and immune health in dogs and cats

Keywords

Probiotic, potential, isolated, canine, feline, microbiota