Efficacy of a 20:1 CBD:THC cannabis herbal extract for pain and inflammation in dogs following TPLO
Efficacy of a 20:1 CBD:THC cannabis herbal extract for pain and inflammation in dogs following TPLO
- 저자: Lyons Chloe; Pinto K Romany; Penney Kira; Holmes Laura; Salama Abdul; Alcorn Jane; Chicoine Alan
- 출처: Frontiers in veterinary science, 2025
- DOI/링크: 10.3389/fvets.2025.1676779
- 분야 태그: #반려동물 #천연물효능
- 정리일: 2026-07-11
TL;DR
Forty-two dogs completed the study
1. 연구 배경 및 동기
- 다루는 문제: This study investigates the efficacy of 20:1 cannabidiol:tetrahydrocannabinol (CBD:THC) cannabis herbal extract (CHE) in reducing pain and improving mobility in dogs undergoing tibial plateau leveling osteotomy (TPLO) for cranial cruciate ligament rupture (CCLr)
2. 관련 연구
- 기존 연구 흐름: This study investigates the efficacy of 20:1 cannabidiol:tetrahydrocannabinol (CBD:THC) cannabis herbal extract (CHE) in reducing pain and improving mobility in dogs undergoing tibial plateau leveling osteotomy (TPLO) for cranial cruciate ligament rupture (CCLr).
- 이 논문의 위치: Natural Product Efficacy Evaluation 분야 내 기존 문헌 검토
| 구분 | 기존 연구 | 이 논문 |
|---|---|---|
| 주제 | 일반적 접근 | Efficacy 중심 |
3. 핵심 기여
- Forty-two dogs completed the study
- All dogs had marked improvement in owner-reported pain scores from days +1 to +14, regardless of treatment group
4. 제안 방법론
- 전체 접근 논리: Forty-eight dogs were enrolled in a randomized, double-blinded, placebo-controlled clinical trial at the Western College of Veterinary Medicine between December 2022 and October 2024
- 단계: Dogs were assigned to one of the three treatment groups: placebo (flavored olive oil), 2 mg CBD (0.1 mg THC)/kg body weight (bw), or 5 mg CBD (0.25 mg THC)/kg bw. All dogs received a standard peri- and post-operative analgesic protocol consisting of opioids, nerve blocks, non-steroidal anti-inflammatory drugs (NSAIDs), and gabapentin
5. 실험 설정
| 항목 | 내용 |
|---|---|
| 대상/재료 | Forty-eight |
| 처리 조건 | Dogs were assigned to one of the three treatment groups: placebo (flavored olive oil), 2 mg CBD (0.1 mg THC)/kg body weight (bw), or 5 mg CBD (0.25 mg THC)/kg bw |
| 대조군 | - |
| 측정 방법 | Data were analyzed using linear mixed models and generalized estimating equations. |
6. 실험 결과 분석
| 지표 | 변화(Δ) | 조건 · 유의성 |
|---|---|---|
| - | - | Forty-two dogs completed the study |
제안 기전(인과 사슬): Forty-two dogs completed the study. All dogs had marked improvement in owner-reported pain scores from days +1 to +14, regardless of treatment group. There were no significant differences in outcome measures between treatment groups
7. 비판적 평가
강점
한계 · 의문
- 표본 크기 및 장기 추적 데이터 부재 가능성
9. 결론
This study investigates the efficacy of 20:1 cannabidiol:tetrahydrocannabinol (CBD:THC) cannabis herbal extract (CHE) in reducing pain and improving mobility in dogs undergoing tibial plateau leveling osteotomy (TPLO) for cranial cruciate ligament rupture (CCLr) 연구에서 forty-eight dogs were enrolled in a randomized, double-blinded, placebo-controlled clinical trial at the western college of veterinary medicine between december 2022 and october 2024을 통해 forty-two dogs completed the study.
Keywords
Efficacy, cannabis, herbal, extract, inflammation, following