Oral dietary supplement with fish oil, ASU and phytotherapeutic extracts in canine osteoarthritis - RCT
Oral dietary supplement with fish oil, ASU and phytotherapeutic extracts in canine osteoarthritis - RCT
- 저자: Palumbo Piccionello Angela; Riccio Valentina; Sassaroli Sara; Tredanari Antonio; Ciabocco Felice; Galosi Margherita; Fordellone Mario; Rossi Giacomo; Pilati Nicola; Dini Fabrizio
- 출처: Frontiers in veterinary science, 2025
- DOI/링크: 10.3389/fvets.2025.1693838
- 분야 태그: #반려동물 #동물건강
- 정리일: 2026-07-11
TL;DR
Overall, Asudyn® proved as effective as, and sometimes superior to, mavacoxib in managing canine OA
1. 연구 배경 및 동기
- 다루는 문제: Osteoarthritis (OA) is a common musculoskeletal disorder in canines, characterized by discomfort, lameness, and reduced mobility
- 기존의 공백 / 왜 필요한가: Because of the inconsistent efficacy of available treatments, and that a definitive resolution can be achieved only in a small number of cases, OA remains a major challenge in veterinary orthopedics. The current strategy is usually a multimodal approach involving systemic administration of anti-inflammatory drugs, intra-articular therapies, physiotherapy, dietary modifications, and nutraceuticals
2. 관련 연구
- 기존 연구 흐름: Thanks to their natural origin and safety, these products have shown promising results in reducing pain and inflammation in dogs with spontaneous osteoarthritis, representing a valuable alternative or complementary option
- 이 논문의 위치: Animal Health 분야 내 기존 문헌 검토
| 구분 | 기존 연구 | 이 논문 |
|---|---|---|
| 주제 | 일반적 접근 | Oral 중심 |
3. 핵심 기여
- Additional parameters included limb circumference (CRF), Total Pressure Index (TPI %), and Gait Lameness Score (GLS %)
- Synovial fluid sampling and radiographic examinations were performed at T0, T30, and T60
- Overall, Asudyn® proved as effective as, and sometimes superior to, mavacoxib in managing canine OA.
4. 제안 방법론
- 전체 접근 논리: The aim of this study was to evaluate the efficacy of a nutraceutical formulation, mainly composed of fish oil, unsaponificable fraction from Avocado and Soy seeds, Turmeric extract, Devil’s Claw, Boswellia, Salix alba extract, Piper nigrum, Haematococcus pluvialis, Magnesium salt of stearic acid, maltodextrin (Asudyn®), by comparing its short- and mid-term clinical, radiographic, and cytological outcomes with those obtained from treatment with mavacoxib (Trocoxil®), a selective COX-2 inhibitor
- 단계: Twenty dogs were enrolled and randomly assigned into two groups. Group A received oral administration of Asudyn® for 90 consecutive days, whereas Group B was treated with Trocoxil® at T0, T15, T45, and T75
5. 실험 설정
| 항목 | 내용 |
|---|---|
| 대상/재료 | Twenty |
| 처리 조건 | Twenty dogs were enrolled and randomly assigned into two groups |
| 대조군 | - |
| 측정 방법 | Lameness was assessed using the Numerical Rating Scale (NRS), pain with the Canine Brief Pain Inventory (CBPI) and Visual Analog Scale (VAS) |
6. 실험 결과 분석
| 지표 | 변화(Δ) | 조건 · 유의성 |
|---|---|---|
| - | - | Additional parameters included limb circumference (CRF), Total Pressure Index (TPI %), and Gait Lameness Score (GLS %) |
제안 기전(인과 사슬): Additional parameters included limb circumference (CRF), Total Pressure Index (TPI %), and Gait Lameness Score (GLS %). Synovial fluid sampling and radiographic examinations were performed at T0, T30, and T60. The results showed that Asudyn® had efficacy comparable to Trocoxil® in reducing pain, improving lameness, and enhancing synovial fluid quality
7. 비판적 평가
강점
- Overall, Asudyn® proved as effective as, and sometimes superior to, mavacoxib in managing canine OA.
한계 · 의문
- 표본 크기 및 장기 추적 데이터 부재 가능성
8. 향후 연구 방향
- Overall, Asudyn® proved as effective as, and sometimes superior to, mavacoxib in managing canine OA.
9. 결론
Osteoarthritis (OA) is a common musculoskeletal disorder in canines, characterized by discomfort, lameness, and reduced mobility 연구에서 the aim of this study was to evaluate the efficacy of a nutraceutical formulation, mainly composed of fish oil, unsaponificable fraction from avocado and soy seeds, turmeric extract, devil’s claw, boswellia, salix alba extract, piper nigrum, haematococcus pluvialis, magnesium salt of stearic acid, maltodextrin (asudyn®), by comparing its short- and mid-term clinical, radiographic, and cytological outcomes with those obtained from treatment with mavacoxib (trocoxil®), a selective cox-2 inhibitor을 통해 additional parameters included limb circumference (crf), total pressure index (tpi %), and gait lameness score (gls %). Overall, Asudyn® proved as effective as, and sometimes superior to, mavacoxib in managing canine OA
Keywords
dietary, supplement, phytotherapeutic, extracts, canine, osteoarthritis